Innovations are always driven by demand. However, achieving an effective management and implementation of innovative solutions as part of regions’ smart specialisation strategies are not as simple as that. They require support from the public sector, strong backup in research and enterprises ready to take on the initiative. But how to ensure such favourable conditions for innovations, taking bio-, circular and digital economy as an example? And what if to apply it to a wider transnational context of the Baltic Sea region? BSR Stars S3, one of Interreg Baltic Sea Region’s projects, is proposing practical methods to stimulate the bio-, circular- and digital economy in the Baltic Sea region.